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AboutPricing
Drug ReportsLactic acid
Lactic acid
Phexxi, Prismasol (lactic acid) is a small molecule pharmaceutical. Lactic acid was first approved as Prismasol bgk 2/0 in plastic container on 2006-10-25. It is used to treat dermatitis and facial dermatoses in the USA. It is known to target hydroxycarboxylic acid receptor 1.
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3M
6M
YTD
1Y
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FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
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Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
skin and connective tissue diseasesD017437
Trade Name
FDA
EMA
Combinations
Phexxi, Prismasol (discontinued: Prismasol)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Calcium chloride
+
Dextrose
+
Lactic acid
+
Magnesium chloride
+
Potassium chloride
+
Sodium bicarbonate
+
Sodium chloride
Tradename
Company
Number
Date
Products
PRISMASOL BGK 2/0 IN PLASTIC CONTAINERBaxterN-021703 RX2006-10-25
1 products, RLD, RS
PRISMASOL BGK 2/3.5 IN PLASTIC CONTAINERBaxterN-021703 RX2006-10-25
1 products, RLD, RS
PRISMASOL BGK 4/2.5 IN PLASTIC CONTAINERBaxterN-021703 RX2006-10-25
1 products, RLD, RS
PRISMASOL BGK 0/2.5 IN PLASTIC CONTAINERBaxterN-021703 RX2006-10-25
1 products, RLD, RS
PRISMASOL B22GK 4/0 IN PLASTIC CONTAINERBaxterN-021703 RX2008-10-10
1 products, RLD, RS
PRISMASOL BK 0/0/1.2 IN PLASTIC CONTAINERBaxterN-021703 RX2008-10-10
1 products, RLD, RS
PRISMASOL BGK 4/0/1.2 IN PLASTIC CONTAINERBaxterN-021703 RX2008-10-10
1 products, RLD, RS
Show 8 discontinued
Citric acid
+
Lactic acid
+
Potassium bitartrate
Tradename
Company
Number
Date
Products
PHEXXIEvofem BiosciencesN-208352 RX2020-05-22
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
ammonium lactateANDA2024-09-20
anubis barcelona new evenOTC monograph final2023-09-01
anubismedOTC monograph final2023-09-05
aoao snow bieach intensive for face and bodyC2002632024-10-18
aoao whitening creamC2002632024-10-13
cheongin haejanghwanunapproved drug other2011-02-18
cheongin haewoohwanunapproved drug other2011-02-18
cheongin samrakhwanunapproved drug other2011-02-17
delflexNew Drug Application2024-10-02
dexrazoxaneANDA2023-10-05
Show 47 more
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
dermatitisHP_0011123D003872L30.9
facial dermatoses—D005148—
urination disorders—D014555—
renal tubular acidosis—D000141N25.89
Agency Specific
FDA
EMA
Expiration
Code
CITRIC ACID / LACTIC ACID / POTASSIUM BITARTRATE, PHEXXI, EVOFEM INC
2023-05-22NP
Patent Expiration
Patent
Expires
Flag
FDA Information
Citric Acid / Lactic Acid / Potassium Bitartrate, Phexxi, Evofem Inc
105688552033-03-15U-1
113379892033-03-15U-1
114396102033-03-15DS, DP
67062762023-09-06DP
ATC Codes
A: Alimentary tract and metabolism drugs
— A07: Antidiarrheals, intestinal antiinflammatory/antiinfective agents
— A07F: Antidiarrheal microorganisms
— A07FA: Antidiarrheal microorganisms
— A07FA01: Lactic acid producing organisms
— A07FA51: Lactic acid producing organisms, combinations
G: Genito urinary system and sex hormones
— G01: Gynecological antiinfectives and antiseptics
— G01A: Antiinfectives and antiseptics, excl. combinations with corticosteroids
— G01AD: Organic acids, gynecological
— G01AD01: Lactic acid
HCPCS
No data
Clinical
Clinical Trials
1395 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
SepsisD018805HP_0100806A41.945846178
ShockD012769—R57.12181554877
Septic shockD012772—A48.32101364567
Healthy volunteers/patients———42713953
HygieneD006920———1404—45
ToxemiaD014115——23323442
HypersensitivityD006967HP_0012393T78.4023332839
Wounds and injuriesD014947—T14.825322637
ObesityD009765EFO_0001073E66.921312633
HyperlactatemiaD065906——31112631
Show 125 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Milk hypersensitivityD016269EFO_0007369——21—1821
EmergenciesD004630———12—1417
NeoplasmsD009369—C80553—617
Premature birthD047928EFO_0003917O60—33—1116
Communicable diseasesD003141————1—1314
Brain injuriesD001930—S06.9155—413
InflammationD007249MP_0001845—111—1113
Traumatic brain injuriesD000070642—S06124—39
Hemorrhagic shockD012771———42—39
FatigueD005221HP_0012378R53.83——1—78
Show 100 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Metabolic syndromeD024821EFO_0000195E88.810—1——1314
Heart arrestD006323EFO_0009492I4614——913
Cardiovascular diseasesD002318HP_0001626——1——1011
Respiratory insufficiencyD012131HP_0002093J96.9—2——79
Renal insufficiencyD051437HP_0000083N1912——68
Food hypersensitivityD005512EFO_1001890——1——78
UlcerD014456MPATH_579——2——46
HerniaD006547HP_0100790K40-K4611——46
Pancreatic neoplasmsD010190EFO_0003860C2522——15
Non-small-cell lung carcinomaD002289——42———5
Show 97 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Insulin resistanceD007333HP_0000855—3———1114
AgingD000375GO_0007568R41.811———78
Systemic inflammatory response syndromeD018746EFO_1001478R65.101———78
Prediabetic stateD011236EFO_1001121R73.033———47
Sickle cell anemiaD000755EFO_0000697D571———56
Post-acute covid-19 syndromeD000094024——1———34
Acute painD059787—R521———23
Liver neoplasmsD008113EFO_1001513C22.01———23
LactationD007774——1———23
MelanomaD008545——2————2
Show 37 more
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Type 1 diabetes mellitusD003922EFO_0001359E10————99
Metabolic diseasesD008659EFO_0000589E88.9————77
ExerciseD015444EFO_0000483—————66
SarcopeniaD055948EFO_1000653M62.84————55
PerfusionD010477——————55
Cutis laxaD003483—Q82.8————55
Body weightD001835EFO_0004338—————55
Severe acute malnutritionD000067011——————55
Healthy dietD000072001——————55
ColitisD003092EFO_0003872K52.9————44
Show 428 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameLactic acid
INN—
Description
2-hydroxypropanoic acid is a 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group. It has a role as a Daphnia magna metabolite and an algal metabolite. It is functionally related to a propionic acid. It is a conjugate acid of a lactate.
Classification
Small molecule
Drug class—
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CC(O)C(=O)O
Identifiers
PDB—
CAS-ID50-21-5
RxCUI1314409
ChEMBL IDCHEMBL1200559
ChEBI ID78320
PubChem CID612
DrugBank—
UNII ID—
Target
Agency Approved
No data
Alternate
HCAR1
HCAR1
Organism
Homo sapiens
Gene name
HCAR1
Gene synonyms
GPR104, GPR81, HCA1
NCBI Gene ID
27198
Protein name
hydroxycarboxylic acid receptor 1
Protein synonyms
G protein-coupled receptor 104, G-protein coupled receptor 104, G-protein coupled receptor 81, hydroxy-carboxylic acid receptor 1, lactate receptor 1, T-cell activation G protein-coupled receptor
Uniprot ID
Q9BXC0
Mouse ortholog
Hcar1 (243270)
hydroxycarboxylic acid receptor 1 (B9EJ36)
Variants
No data
Financial
Revenue by drug
$
€
£
₣
Phexxi – Evofem Biosciences
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Estimated US medical usage
Lactic acid
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 955,907 documents
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Safety
Black-box Warning
Black-box warning for: Haloperidol, Haloperidol lactate, Perseris, Prenate enhance, Prenate restore
Adverse Events
Top Adverse Reactions
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100,674 adverse events reported
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