Lactic acid
Phexxi, Prismasol (lactic acid) is a small molecule pharmaceutical. Lactic acid was first approved as Prismasol bgk 2/0 in plastic container on 2006-10-25. It is used to treat dermatitis and facial dermatoses in the USA. It is known to target hydroxycarboxylic acid receptor 1.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| skin and connective tissue diseases | D017437 |
Trade Name
FDA
EMA
Combinations
Phexxi, Prismasol
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Calcium chloride
+
Dextrose
+
Lactic acid
+
Magnesium chloride
+
Potassium chloride
+
Sodium bicarbonate
+
Sodium chloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| PRISMASOL B22GK 4/0 IN PLASTIC CONTAINER | Baxter | N-021703 RX | 2008-10-10 | 1 products, RLD, RS |
| PRISMASOL BK 0/0/1.2 IN PLASTIC CONTAINER | Baxter | N-021703 RX | 2008-10-10 | 1 products, RLD, RS |
| PRISMASOL BGK 4/0/1.2 IN PLASTIC CONTAINER | Baxter | N-021703 RX | 2008-10-10 | 1 products, RLD, RS |
| PRISMASOL BGK 2/0 IN PLASTIC CONTAINER | Baxter | N-021703 RX | 2006-10-25 | 1 products, RLD, RS |
| PRISMASOL BGK 2/3.5 IN PLASTIC CONTAINER | Baxter | N-021703 RX | 2006-10-25 | 1 products, RLD, RS |
| PRISMASOL BGK 4/2.5 IN PLASTIC CONTAINER | Baxter | N-021703 RX | 2006-10-25 | 1 products, RLD, RS |
| PRISMASOL BGK 0/2.5 IN PLASTIC CONTAINER | Baxter | N-021703 RX | 2006-10-25 | 1 products, RLD, RS |
Show 8 discontinued
Citric acid
+
Lactic acid
+
Potassium bitartrate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| PHEXXI | Evofem Biosciences | N-208352 RX | 2020-05-22 | 1 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| anubis barcelona new even | OTC monograph final | 2023-09-01 |
| anubismed | OTC monograph final | 2023-09-05 |
| delflex | New Drug Application | 2023-10-19 |
| dexrazoxane | ANDA | 2022-07-18 |
| dextrose | 2006-06-22 | |
| dextrose and electrolyte no. 48 | New Drug Application | 2020-02-13 |
| dextrose in lactated ringer's | 2008-09-03 | |
| dextrose in lactated ringers | New Drug Application | 2021-06-01 |
| dianeal low calcium peritoneal dialysis solution with dextrose dianeal pd-2 peritoneal dialysis solution with dextrose | New Drug Application | 2013-06-30 |
| dianeal low calcium with dextrose dianeal pd-2 with dextrose | New Drug Application | 2019-11-21 |
Show 19 more
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| dermatitis | HP_0011123 | D003872 | L30.9 |
| facial dermatoses | — | D005148 | — |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
CITRIC ACID / LACTIC ACID / POTASSIUM BITARTRATE, PHEXXI, EVOFEM INC | |||
| 2023-05-22 | NP | ||
ATC Codes
A: Alimentary tract and metabolism drugs
— A07: Antidiarrheals, intestinal antiinflammatory/antiinfective agents
— A07F: Antidiarrheal microorganisms
— A07FA: Antidiarrheal microorganisms
— A07FA01: Lactic acid producing organisms
— A07FA51: Lactic acid producing organisms, combinations
G: Genito urinary system and sex hormones
— G01: Gynecological antiinfectives and antiseptics
— G01A: Antiinfectives and antiseptics, excl. combinations with corticosteroids
— G01AD: Organic acids, gynecological
— G01AD01: Lactic acid
HCPCS
No data
Clinical
Clinical Trials
1295 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Septic shock | D012772 | — | A48.3 | 2 | 7 | 11 | 6 | 41 | 60 |
| Sepsis | D018805 | HP_0100806 | A41.9 | 2 | 3 | 5 | 3 | 46 | 57 |
| Hygiene | D006920 | — | — | — | 1 | 40 | 4 | — | 45 |
| Healthy volunteers/patients | — | — | — | 4 | 1 | 7 | 1 | 28 | 41 |
| Obesity | D009765 | EFO_0001073 | E66.9 | 1 | — | 2 | 1 | 23 | 27 |
| Shock | D012769 | — | R57.1 | — | 3 | 2 | 1 | 16 | 21 |
| Covid-19 | D000086382 | — | U07.1 | 2 | 3 | 1 | 1 | 12 | 18 |
| Acute kidney injury | D058186 | HP_0001919 | N17 | — | — | — | 2 | 15 | 17 |
| Critical illness | D016638 | — | — | — | — | 1 | 3 | 12 | 16 |
| Lactic acidosis | D000140 | HP_0003128 | E87.20 | — | 5 | 1 | 3 | 6 | 14 |
Show 62 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Milk hypersensitivity | D016269 | EFO_0007369 | — | — | 2 | 1 | — | 14 | 17 |
| Hyperlactatemia | D065906 | — | — | 2 | 1 | 1 | — | 12 | 15 |
| Inflammation | D007249 | MP_0001845 | — | — | 1 | 1 | — | 10 | 11 |
| Neoplasms | D009369 | — | C80 | 4 | 1 | 2 | — | 3 | 10 |
| Hemorrhagic shock | D012771 | — | — | — | 4 | 2 | — | 3 | 9 |
| Pancreatitis | D010195 | HP_0001733 | K85 | — | 2 | 4 | — | 4 | 8 |
| Prostatic neoplasms | D011471 | — | C61 | 3 | 4 | 2 | — | — | 7 |
| Macular degeneration | D008268 | EFO_0001365 | H35.30 | — | 5 | 2 | — | — | 7 |
| Traumatic brain injuries | D000070642 | — | S06 | 1 | 2 | 3 | — | 2 | 7 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | 1 | 2 | — | 1 | 5 |
Show 55 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 1 | 2 | — | — | 7 | 10 |
| Malnutrition | D044342 | EFO_0008572 | E40-E46 | — | 1 | — | — | 8 | 9 |
| Heart arrest | D006323 | EFO_0009492 | I46 | 1 | 4 | — | — | 5 | 9 |
| Respiratory insufficiency | D012131 | HP_0002093 | J96.9 | — | 1 | — | — | 7 | 8 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 2 | 1 | — | — | 1 | 4 |
| Non-small-cell lung carcinoma | D002289 | — | — | 3 | 2 | — | — | — | 4 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | — | 1 | — | — | 2 | 3 |
| Hypoxia | D000860 | HP_0012418 | R09.02 | 1 | 1 | — | — | 2 | 3 |
| Macular edema | D008269 | — | — | 1 | 2 | — | — | — | 2 |
| Pancreatic ductal carcinoma | D021441 | — | — | 1 | 1 | — | — | — | 2 |
Show 53 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Insulin resistance | D007333 | HP_0000855 | E88.819 | 2 | — | — | — | 10 | 12 |
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | 1 | — | — | — | 4 | 5 |
| Aging | D000375 | GO_0007568 | R41.81 | 1 | — | — | — | 3 | 4 |
| Acute pain | D059787 | — | R52 | 1 | — | — | — | 2 | 3 |
| Peripheral arterial disease | D058729 | EFO_0004265 | — | 1 | — | — | — | 2 | 3 |
| Lactation | D007774 | — | — | 1 | — | — | — | 2 | 3 |
| Epilepsy | D004827 | EFO_0000474 | G40.9 | 1 | — | — | — | 1 | 2 |
| Vulvovaginal candidiasis | D002181 | EFO_0007543 | B37.3 | 1 | — | — | — | 1 | 2 |
| Prediabetic state | D011236 | EFO_1001121 | R73.03 | 2 | — | — | — | — | 2 |
| Uveal neoplasms | D014604 | EFO_1001230 | — | 1 | — | — | — | — | 1 |
Show 14 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cardiovascular diseases | D002318 | HP_0001626 | — | — | — | — | — | 9 | 9 |
| Metabolic syndrome | D024821 | EFO_0000195 | E88.810 | — | — | — | — | 7 | 7 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | — | — | — | — | 7 | 7 |
| Systemic inflammatory response syndrome | D018746 | EFO_1001478 | R65.10 | — | — | — | — | 6 | 6 |
| Sarcopenia | D055948 | EFO_1000653 | M62.84 | — | — | — | — | 5 | 5 |
| Exercise | D015444 | EFO_0000483 | — | — | — | — | — | 5 | 5 |
| Acidosis | D000138 | EFO_1000014 | E87.2 | — | — | — | — | 5 | 5 |
| Severe acute malnutrition | D000067011 | — | — | — | — | — | — | 5 | 5 |
| Hypercholesterolemia | D006937 | HP_0003124 | — | — | — | — | — | 4 | 4 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | — | — | — | 4 | 4 |
Show 288 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Lactic acid |
| INN | — |
| Description | 2-hydroxypropanoic acid is a 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group. It has a role as a Daphnia magna metabolite and an algal metabolite. It is functionally related to a propionic acid. It is a conjugate acid of a lactate. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(O)C(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 50-21-5 |
| RxCUI | 1314409 |
| ChEMBL ID | CHEMBL1200559 |
| ChEBI ID | 78320 |
| PubChem CID | 612 |
| DrugBank | — |
| UNII ID | — |
Target
Agency Approved
No data
Alternate
HCAR1
HCAR1
Organism
Homo sapiens
Gene name
HCAR1
Gene synonyms
GPR104, GPR81, HCA1
NCBI Gene ID
Protein name
hydroxycarboxylic acid receptor 1
Protein synonyms
G protein-coupled receptor 104, G-protein coupled receptor 104, G-protein coupled receptor 81, hydroxy-carboxylic acid receptor 1, lactate receptor 1, T-cell activation G protein-coupled receptor
Uniprot ID
Mouse ortholog
Hcar1 (243270)
hydroxycarboxylic acid receptor 1 (B9EJ36)
Variants
No data
Financial
Revenue by drug
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Phexxi – Evofem Biosciences
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Estimated US medical usage
Lactic acid
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,019,147 documents
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Safety
Black-box Warning
Black-box warning for: Haloperidol, Haloperidol lactate, Prenate enhance, Prenate restore
Adverse Events
Top Adverse Reactions
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92,017 adverse events reported
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